全文获取类型
收费全文 | 7716篇 |
免费 | 543篇 |
国内免费 | 180篇 |
专业分类
耳鼻咽喉 | 55篇 |
儿科学 | 118篇 |
妇产科学 | 73篇 |
基础医学 | 1413篇 |
口腔科学 | 932篇 |
临床医学 | 852篇 |
内科学 | 532篇 |
皮肤病学 | 33篇 |
神经病学 | 1654篇 |
特种医学 | 233篇 |
外科学 | 372篇 |
综合类 | 650篇 |
预防医学 | 263篇 |
眼科学 | 240篇 |
药学 | 569篇 |
3篇 | |
中国医学 | 276篇 |
肿瘤学 | 171篇 |
出版年
2024年 | 8篇 |
2023年 | 147篇 |
2022年 | 206篇 |
2021年 | 447篇 |
2020年 | 344篇 |
2019年 | 305篇 |
2018年 | 288篇 |
2017年 | 248篇 |
2016年 | 256篇 |
2015年 | 234篇 |
2014年 | 416篇 |
2013年 | 504篇 |
2012年 | 353篇 |
2011年 | 400篇 |
2010年 | 319篇 |
2009年 | 341篇 |
2008年 | 374篇 |
2007年 | 328篇 |
2006年 | 313篇 |
2005年 | 273篇 |
2004年 | 237篇 |
2003年 | 211篇 |
2002年 | 195篇 |
2001年 | 143篇 |
2000年 | 127篇 |
1999年 | 102篇 |
1998年 | 101篇 |
1997年 | 101篇 |
1996年 | 89篇 |
1995年 | 77篇 |
1994年 | 70篇 |
1993年 | 56篇 |
1992年 | 49篇 |
1991年 | 59篇 |
1990年 | 54篇 |
1989年 | 59篇 |
1988年 | 37篇 |
1987年 | 63篇 |
1986年 | 52篇 |
1985年 | 72篇 |
1984年 | 78篇 |
1983年 | 56篇 |
1982年 | 54篇 |
1981年 | 47篇 |
1980年 | 47篇 |
1979年 | 26篇 |
1978年 | 28篇 |
1977年 | 14篇 |
1976年 | 6篇 |
1973年 | 8篇 |
排序方式: 共有8439条查询结果,搜索用时 15 毫秒
71.
OBJECTIVE: (a) To describe the changes in electromyographic (EMG) activity from selected jaw muscles during a standardized lateral jaw movement with the teeth together, and (b) to investigate the effects on jaw muscle activity of changes in both the rate of lateral jaw movement and the relative magnitude of jaw-closing force. DESIGN: In 16 healthy volunteers, recordings were made using a jaw-tracking system, of mid-incisor point (MIPT) movements, as well as EMG activity from the contralateral inferior head of the lateral pterygoid muscle (IHLP), and bilateral anterior and posterior temporalis, masseter and submandibular muscles, during lateral jaw movement tasks at two speeds and two closing force levels with the teeth together. RESULTS: The IHLP was the only muscle to show a consistent increase in activity in association with the outgoing phase of the task and a decrease during the return phase. Under high closing force at slow speed, the EMG activities of the IHLP and bilateral anterior temporalis and masseter muscles were significantly (p < 0.05) higher than those under a low closing force, while there was no significant change (p > 0.05) in bilateral posterior temporalis and submandibular muscles. The change from slow to fast lateral movement at low force did not significantly (p > 0.05) alter the mean activity except for the IHLP (increase in activity) and the contralateral anterior temporalis (decrease in activity). CONCLUSIONS: The data suggest that the IHLP is one of the principal jaw muscles involved in a lateral jaw movement with the teeth together while the other jaw muscles may play a contributory or facilitatory role. 相似文献
72.
Yasser Kheralla Werner Götz Afshar Kawarizadeh B. Rath-Deschner Andreas Jäger 《Archives of oral biology》2010,55(3):215-222
Objective
To characterize in vivo the role of IGF-I and its signalling, as an early reaction in the mechanotransduction process and to analyse changes of the local expression related to the magnitude of the applied force.Materials and methods
Forces of 0.1 N, 0.25 N and 0.5 N were applied to move the right upper first molars of 12 anaesthetized rats mesially. These forces were kept constant for 4 h. The untreated contralateral side served as a control. Paraffin-embedded sections of the resected jaws were prepared for immunohistochemistry to localize insulin-like growth factor-I (IGF-I), its receptor (IGF-IR), and insulin receptor substrate 1 (IRS1). Histomorphometric analysis was performed to count the percentage of immunoreactive cells in different parts of the periodontal ligament.Results
IGF-I, IGF-IR and IRS1 positive cells were observed in the periodontal tissues of the control and loaded teeth. In the experimental group, the number of IGF-I-, IGF-IR- and IRS1-positive cells increased significantly on the tension side and decreased on the compression side.Conclusions
These data indicate a close relationship between mechanical loading of the PDL and the autocrine/paracrine expression of IGF components as an early step in the mechanotransduction process leading in the long term to an organized remodelling of the alveolar bone. 相似文献73.
目的:探讨颞下颌关节紊乱病(TMD)患者的下颌咀嚼运动轨迹特点,及其与症状和咬合异常的关系。方法:23名无症状大学生志愿者和130名TMD患者,取研究模,记录咀嚼运动[牙合]期轨迹。结果:无症状对照组和TMD组咀嚼运动[牙合]期轨迹的形态没有显著差异(P〉0.05)。TMD组矢状面咀嚼运动轨迹的ICP稳定比例明显低于对照组(P〈0.01),但冠状面上咀嚼运动轨迹的ICP稳定比例两组间无明显差异(P〉0.05)。TMD组矢状面[牙合]期轨迹分型与近远中向咬合关系的3级计分存在明显相关关系(P〈0.01),近远中向咬合关系不正常者出现不重合型轨迹的比例较高。疼痛和关节弹响症状与咀嚼运动[牙合]期轨迹形态无关。结论:近远中向咬合关系对咀嚼运动有明显的引导作用。 相似文献
74.
Stress distribution of abutments and base displacement with precision attachment- and telescopic crown-retained removable partial dentures 总被引:9,自引:0,他引:9
Five types of removable partial dentures (two attachment dentures, two telescopic dentures and one clasp denture) were designed. The two attachment dentures were retained by the rigid-precision attachments with or without a stabilizing arm, and the two telescope dentures were retained with cone telescope crowns with or without cross-arch stabilization. The stresses acting on abutment teeth and denture bases and the movements of denture bases were investigated, and the influences of denture design were clarified. The stress acting on a terminal abutment tooth retained by a rigid-precision attachment or cone telescopic crown was larger than that acting on a terminal abutment tooth retained by a clasp. The attachment dentures tended to concentrate more stress at the terminal abutment tooth than did the telescopic dentures. The stress of denture base of an attachment denture and a telescopic denture was less than that of a clasp denture. There was no difference between the stresses of attachment and telescopic dentures. The displacement of the denture base tended to be less when the denture was designed with a rigid connection for the retainer and with cross-arch stabilization. 相似文献
75.
局部应用二磷酸盐对鼠正畸牙移动影响的研究 总被引:3,自引:0,他引:3
目的 探讨局部注射Zoledronate溶液对鼠正畸牙齿移动距离与牙周组织形态的影响。方法 选用42只雄性Wistar大鼠,牵引其上颌第一磨牙近中移动。实验中分别将Zoledronate溶液及生理盐水注射入实验组(左侧)及对照组大鼠(双侧)上颌第一磨牙腭侧的粘骨膜下。注射于实验前3d开始,共进行9次,每3d一次。分别在加力0、3、7、14、21d后记录上颌第一磨牙移动距离,组织HE染色后,观察牙周组织形态学的改变。结果 ①实验组大鼠牙齿移动距离明显低于对照组。②实验组大鼠压力侧破骨细胞数在实验全过程中均低于对照组,而根分叉区破牙骨质细胞数除加力14d外,2组差异无显著性。③实验过程中Zoledronate溶液对破骨细胞和破牙骨质细胞以外的细胞作用不明显。结论 Zoledronate能有效地抑制支抗牙移动,减少压力侧牙槽骨表面破骨细胞数。 相似文献
76.
The aim of this study was to clarify the influence of masticatory function on dental arch forms. We evaluated the relationship between the masticatory movement path and occlusal force (as masticatory function) and the dental arch width and first molar bucco-lingual inclination. The subjects were 60 healthy adult females (mean 23.4 years; S.D. 1.6 years) without previous orthodontic treatment or functional abnormalities in the temporomandibular joint. Furthermore, the subjects were divided into a wide group (W-group) and a narrow group (N-group) based on mean maxillary inter-molar width in Japanese females. The masticatory path was recorded using gnathohexagraph system. Maximum occlusal force was measured using a simple type occlusal force meter. And subjects’ arch width and bucco-lingual inclination of the first molars was measured. W-group showed larger arch width and the first molar was more upright on the buccal side compared with N-group. Furthermore, the lateral component of masticatory movement and maximum occlusal force was large in W-group compared with N-group. In the group which strong occlusal force and grinding type mastication had wide arch width and the mandibular first molars upright on the buccal side. 相似文献
77.
Suda N 《Orthodontics & craniofacial research》2008,11(1):1-7
OBJECTIVES: The periodontal ligament (PDL) is thought to be an important tissue in vertical movement during tooth eruption, but the precise molecular mechanism is not known. Thereto, comprehensive gene expression was analyzed in human PDL of mandibular third molars performing vertical movement and maxillary second premolars with occlusal contact. DESIGN: The expression profile of 9,243 genes in the PDL of one subject was compared between vertically moving third molars and second premolars with occlusal contact by DNA microarray. RESULTS: The expression of 27 genes showed more than a 10-fold difference between third molars and second premolars. The expression of CALB1 (encoding calbindin 1), CYP26A1 (encoding cytochrome P450, family 26, subfamily A, polypeptide 1), SPOCK3 (encoding testican-3), CCK (encoding cholecystokinin) and SCRG1 (encoding scrapie responsive protein 1) was more than 30-fold higher in PDLs of the third molars than the second premolars. CALB1 is reported to increase at the pressure side of PDL during experimental orthodontic tooth movement in rats. Interestingly, in this study, CALB1 expression showed the largest difference. In contrast, CRCT1 (encoding cysteine-rich C-terminal 1), SPRP3 (encoding small proline-rich protein 3), IL8 (encoding interleukin 8) and MMP12 (encoding matrix metalloproteinase 12) showed more than 100-fold higher expression in PDLs of the second premolars than the third molars. CONCLUSION: The present comprehensive gene expression in PDLs provides new insights into the molecular mechanism during the vertical tooth movement. 相似文献
78.
上颌第三磨牙对第一磨牙近中移动影响的研究 总被引:1,自引:0,他引:1
目的探讨萌出中的上颌第三磨牙是否会使上颌第一磨牙向近中移动。方法选择18~24岁正畸患者18例,均拔除4颗第一前磨牙矫治,且随机拔除一侧上颌第三磨牙,两侧其余治疗条件保持一致。治疗3个月后观察两侧上颌第一磨牙近中移动量是否存在差异。结果1)拔除上颌第三磨牙的一侧,其上颌第一磨牙在治疗3个月后未发生明显的近中移动;2)未拔除上颌第三磨牙的一侧,其上颌第一磨牙在治疗3个月后的近中移动量为1mm;3)治疗3个月后,未拔除上颌第三磨牙侧的第一磨牙近中移动量大于拔除第三磨牙侧的第一磨牙的近中移动量,其差异有统计学意义(P<0.01)。结论在正畸治疗的初始阶段,若上颌第三磨牙的萌出间隙不足,其萌出会对其近中的上颌第一磨牙产生影响,导致其近中移动而丧失支抗。 相似文献
79.
Fujita S Yamaguchi M Utsunomiya T Yamamoto H Kasai K 《Orthodontics & craniofacial research》2008,11(3):143-155
OBJECTIVE: Recent studies have demonstrated that low-energy laser irradiation stimulates bone formation in vitro and in vivo. However, very little is known about the effects of laser irradiation on osteoclastogenesis. The receptor activator of the nuclear factor-kB (RANK) / RANK ligand (RANKL) / osteoprotegerin (OPG) system is essential and sufficient for osteoclastogenesis. The present study was designed to examine the effects of low-energy laser irradiation on expressions of RANK, RANKL, and OPG during experimental tooth movement. DESIGN: To induce experimental tooth movement in rats, 10 g of orthodontic force was applied to the molars. Next, a Ga-Al-As diode laser was used to irradiate the area around the moved tooth and the amount of tooth movement was measured for 7 days. Immunohistochemical staining with RANK, RANKL, and OPG was performed. Real time PCR was also performed to elucidate the expression of RANK in irradiated rat osteoclast precursor cells in vitro. RESULTS: In the irradiation group, the amount of tooth movement was significantly greater than in the non-irradiation group by the end of the experimental period. Cells that showed positive immunoreactions to the primary antibodies of RANKL and RANK were significantly increased in the irradiation group on day 2 and 3, compared with the non-irradiation group. In contrast, the expression of OPG was not changed. Further, RANK expression in osteoclast precursor cells was detected at an early stage (day 2 and 3) in the irradiation group. CONCLUSION: These findings suggest that low-energy laser irradiation stimulates the velocity of tooth movement via induction of RANK and RANKL. 相似文献
80.
目的:通过比较CBFa1/Osf2和BMPs在牙周组织中的表达及变化,探讨在正畸骨改建过程中,这两个对骨形成起到重要作用的因子之间的相互关系,为进一步深入研究正畸牙移动的生物学机制奠定基础。方法:建立大鼠正畸牙移动的动物模型,并采用免疫组织化学的方法检测CBFa1/Osf2和BMPs在此过程中的表达。结果:正畸牙移动过程中CBFa1/Osf2和BMPs在牙周组织的分布及表达变化的时间上具有明显的一致性;均表现为实验组表达明显强于对照组,张力侧表达强于压力侧;其中成骨细胞、成纤维细胞及破骨细胞均为强表达。结论:CBFa1/Osf2和BMPs均参与了正畸的骨改建过程,且可能在正畸骨改建中起到重要作用。 相似文献